Buying Them Off or Scaring Them Straight: Explaining Warlord Democrats’ Electoral Rhetoric

Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?

Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications...

Scaring Offenders Straight

D eterrence is based on the notion that people consciously try to avoid pain and seek pleasure. It follows that by making a choice painful enough—such as the choice of crime—individuals will choose not to engage in the act. Across society as a whole, this perspective would predict that crime rates would be lowest in those places where offending evokes the most “pain” (or costs) and highest in t...

Quasars: What Turns Them Off?

While the high-redshift quasar luminosity function closely parallels the hierarchical growth of dark matter halos, at lower redshifts quasars exhibit an anti-hierarchical turn-off, which moves from the most luminous objects to the faintest. We explore the idea that this may arise from self-regulating feedback, caused by quasar outflows. Using a detailed hydrodynamic simulation we calculate the ...

Wear them, forget them.

Build them up and break them down

Tight junctions (TJs) of cells expressing simple epithelial polarity have been extensively studied, but less is known about TJs of cells expressing complex polarity. In this paper we analyzed, TJs of four different lines, that form bile canaliculi (BC) and express typical hepatocyte polarity; WIF-B9, 11-3, Can 3-1, Can 10. Striking differences were observed in claudin expression. None of the ce...